From the very first episode, Doc captures the heart, drawing viewers into an emotional journey through the highs and lows of life in medicine. This American medical drama, inspired by the Italian hit Doc – Nelle tue mani, has become a fan favorite in just 10 days, quickly climbing to the #2 spot in Netflix’s top 10 TV shows. The show follows Dr. Amy Larsen (Molly Parker), a brilliant chief of internal medicine who wakes up from a traumatic brain injury with eight years of her memory erased.
As she struggles to reconnect with colleagues, rebuild relationships, and find her place in the hospital once again, Doc explores themes of identity, resilience, and the emotional challenges faced by medical professionals. Praised for its heartfelt storytelling and rich character development, the show has resonated deeply with audiences nationwide. Here is everything you need to know about Doc – from the plot and cast to reviews and release date. The trailer is at the bottom of the article.
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Doc – all the key details
- Title: Doc
- Format: Show
- Runtime: Season 1: 10 episodes; Season 2: ongoing
- Genre: Medical drama
- Country of production: United States
- Original language: English
- Release date: Season 1: January 7, 2025; Season 2: September 14, 2025
- Director / Creator: Barbie Kligman
- Lead cast: Molly Parker, Omar Metwally, Jon Ecker, Amirah Vann
- Produced by: Fox Entertainment, Sony Pictures Television
What Doc is about
Doc centers on Dr. Amy Larsen, a dedicated physician who wakes up from a car accident with eight years of her memory completely erased. During that time, her life changed in ways she cannot remember. She went through a divorce, strained her closest relationships, and made a medical mistake that pushed her away from the people around her. Now, returning to her role at Westside Hospital in Minneapolis, Amy must navigate a world that feels both familiar and foreign. She faces the challenge of reconnecting with colleagues, rebuilding trust with patients, and reclaiming a career she barely recognizes.
At the same time, she must confront the emotional weight of her past and the professional consequences of her amnesia. Along the way, the show follows her journey of self-discovery, emotional healing, and the struggle to balance her career with her personal life. With its heartfelt storytelling and richly drawn characters, Doc draws viewers into the intense and emotional world of medicine, highlighting both the triumphs and vulnerabilities of those who dedicate their lives to caring for others.
Doc cast and main characters
The heart of Doc is Molly Parker as Dr. Amy Larsen, navigating her professional and personal life after losing eight years of memories. Omar Metwally plays Dr. Michael Hamda, Amy’s ex-husband and the hospital’s chief medical officer, while Jon Ecker is Dr. Jake Heller, a compassionate resident who supports Amy through her recovery. Amirah Vann portrays Dr. Gina Walker, a neuropsychiatrist and close friend. Among the younger staff, Anya Banerjee and Patrick Walker stand out, while Charlotte Fountain-Jardim and Felicity Huffman join in Season 2.
Is Doc based on a true story?
Yes, Doc is inspired by the real-life experiences of Dr. Pierdante Piccioni, a former chief of the emergency room in Lodi and Codogno, Italy. In 2013, Dr. Piccioni suffered a traumatic brain injury that caused him to lose all memories of the previous 12 years of his life. His journey of rediscovery and the challenges he faced in reconnecting with his profession and personal life served as the foundation for both the Italian show Doc – Nelle tue mani and its American adaptation.
What reviews say about Doc
Doc has received commendations for its compelling storytelling and strong performances. Variety praised the show as a “fascinating analysis of medicine, human nature, and how medical providers’ personal and professional lives are often interconnected.” Additionally, Doc has resonated with audiences on streaming platforms. Since its release on Netflix, the series has climbed to the #2 spot in the platform’s top 10 TV shows, indicating a strong viewer preference and engagement.
Where was Doc filmed?
Doc was primarily filmed in Toronto, Canada. The city’s diverse architecture and versatile locations provided a suitable backdrop for the fictional setting of Minneapolis, where the series is set. Toronto’s well-established film industry infrastructure also facilitated the production’s high-quality visuals and efficient shooting schedule.
When to watch Doc
Available now. Doc is already streaming on Netflix, where it has climbed to the #2 spot in the Top 10 TV Shows. Release date: September 23, 2025. Watch on Netflix.
Watch the trailer
Here’s the trailer to get a first taste.
